Cardiovascular Health

#mce_temp_url#Oil Research Subpage Header


Diets enriched with conventional of high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity.
Bowen KJ, Kris-Etherton PM, West SG, Fleming JA, Connelly PW, Lamarche B, Couture P, Jenkins DJA, Taylor CG, Zahradka P, Hammad S, Sihag J, Chen X, Guay V, Maltais-Giguère J, Perera D, Wilson A, Juan SCS, Rempel J, Jones PJH. J Nutr 2019: 149(3): 471-478.

Effects of canola oil consumption on lipid profile: A systematic review and meta-analysis of randomized controlled clinical trials
Bowen KJ, Kris-Etherton PM, West SG, Fleming JA, Connelly PW, Lamarche B, Couture P, Jenkins DJA, Taylor CG, Zahradka P, Hammad S, Sihag J, Chen X, Guay V, Maltais-Giguère J, Perera D, Wilson A, Juan SCS, Rempel J, Jones PJH. J Nutr 2019: 149(3): 471-478.


Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome: The Canola Oil Multicenter Intervention Trial
Liu X., Garban J., Jones PJ., Vanden Heuvel, J., Lamarche B., Jenkins DJ., Connelly PW., Couture P.,  Pu S.,  Fleming  JA.,  West  SG., Kris-Etherton PM. J Nutr 2018:148(5):721-728.


How canola and sunflower oils affect lipid profile and anthropometric parameters of participants with dyslipidemia.
Saedi, S., Noroozi, M., Khosrotabar, N., Mazandarani, S., Ghadrdoost, B. Med J Islam Repub Iran 2017:31:5


Dietary high oleic canola oil supplemented with docosahexaenoic acid attenuates plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels in participants with cardiovascular disease risk: A randomized control trial.
Pu, S., Rodriguez-Perez, C., Ramprasath, V. R., Segura-Carretero, A., and Jones, P. J. Vascul Pharmacol 2016: 87:60-65. 

Rice bran oil and canola oil improve blood lipids compared to sunflower oil I women with type 2 diabetes: A randomized, single blind controlled trial.
Salar, A., Faghih, S, Pishdad, G-R. J Clin Lipidol March-April 2016 10(2): 299-305.

Docosahexaenoic acid attenuates cardiovascular risk factors via a decline in proprotein convertase subtilisin/kexin type 9 (PCSK9) plasma levels.
Rodriguez-Perez, C., Ramprasath, V.R., Pu, S., Sabra, A., Quirantes-Pine, R., Segura-Carretero, A., and Jones, P.J. Lipids 2016; 51(1): 75-83.


Dietary rapeseed/canola-oil supplementation reduces serum lipids and liver enzymes and alters postprandial inflammatory responses in adipose tissue compared to olive-oil supplementation in obese men.
Kruse, M., von Loeffeholz, C., Hoffman, D., Pohlmann, A., Seltmann, A-C., Osterhoff, M., Hornemann, S., Pivovarova, O., Rohn, S., Jahreis, G., Pfeiffer, A. Mol Nutr Food Res 2015; 59:507-519

Docosahexaenoic acid-enriched canola oil increases adiponectin concentrations: a randomized crossover controlled intervention trial.
Baril-Gravel, L., Labonte, M. E., Couture, P., Vohl, M. C., Charest, A., Guay,V., Jenkins, D.A., Connelly,P.W., West, S., Kris-Etherton,, P.M., Jones, P.J., Fleming, J.A., and Lamarche, B. Nutr Metab Cardiovasc Dis 2015; 25(1): 52-59.

High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans.
Jones, P. J., MacKay, D.S., Senanayake, V.K., Pu, S., Jenkins, D.J., Connelly, P.W.,  Lamarche, B., Couture, P., Kris-Etherton, P.M., West, S.G., Liu, X., Fleming, J.A.,  Hantgan, R.R. and Rudel L.L.  Atherosclerosis  2015; 238(2): 231-238.

Effect of a low-fat diet enriched either with rapeseed oil or sunflower oil on plasma lipoproteins in childrenand adolescents with familial hypercholesterolaemia. Results of a pilot study.
Negele, L., Schneider, B., Ristl, R.,Stulnig, T.M., Willfort-Ehringer, A., Helk, O. and Widhalm, K. Eur J Clin Nutr 2015; 69:337-343.


DHA-enriched high–oleic acid canola oil improves lipid profile and lowers predicted cardiovascular disease risk in the canola oil multicenter randomized controlled trial
Jones PJH, Senanayake VK, Pu S. Jenkins DJA, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea C, Kris-Etherton PMK. Am J Clin Nutr2014; 100 (1):88-97.


High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects
Gillingham LG, Gustafson JA, Han SY, Jassal DS, Jones PJH. Br J Nutr 2011; 105(3):417-27

Replacing dairy fat with rapeseed oil causes rapid improvement of hyperlipidaemia: a randomized controlled study
Iggman D, Gustafsson IB, Berglund L, Vessby B, Marckmann P, Riserus U. J Intern Med 2011; 270:356-364


Effects of dietary cold-pressed turnip rapeseed oil and butter on serum lipids, oxidized LDL and arterial elasticity in men with metabolic syndrome
Palomaki A, Pohjantahti-Maaroos  H, Wallenius M, Kankkunen P, Aro H, Husgafvel S, Pihlava  JM, Oksanen K. Lipids Health Dis 2010 Dec 1;9:137. doi: 10.1186/1476-511X-9-137

Elevated plasma fibrinogen caused by inadequate α-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil
Seppänen-Laakso T, Laakso I, Lehtimäki T, Rontu R, Moilanen E, Solakivi T, Seppo L, Vanhanen H, Kiviranta K, Hiltunen R. Prostaglandins Leukot Essent Fatty Acids 2010 Jul;83(1):45-54.

Alpha-Linolenic Acid and Risk of Nonfatal Acute Myocardial Infarction.
Campos H, Baylin A, Willett WC. Circulation 2008; 118:339-345.


Home use of vegetable oils, markers of systemic inflammation, and endothelial dysfunction among women
Esmaillzadeh A, Azadbakht L, Am J Clin Nutr 2008; 88:913.

Canola oil decreases cholesterol and improves endothelial function in patients with peripheral arterial occlusive disease - a pilot study.
Stricker H, Duchini F, Facchini M, Mombelli G. Artery Research 2008; 2:67.

Characteristics of the diet patterns tested in the optimal macronutrient intake trial to prevent heart disease (OmniHeart): options for a heart-healthy diet.
Swain JF, McCarron PB, Hamilton EF, Sacks FM, Appel LJ. J Am Diet Assoc 2008; 108:257.


Influence of three rapeseed oil-rich diets, fortified with a-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on the composition and oxidizability of low-density lipoproteins: results of a controlled study in healthy volunteers.
Egert S, Somoza V, Kannenberg  F, Fobker M, Krome K, Erbersdobler HF, Wahrburg U. Eur J Clin Nutr 2007;61:314

Postprandial effect of n–3 polyunsaturated fatty acids on apolipoprotein B–containing lipoproteins and vascular reactivity in type 2 diabetes.
Hilpert, KF, West SG, Kris-Etherton PM, Hecker KD, Simpson NM, Alaupovic  P. Am J Clin Nutr  2007; 85: 369


Phytosterols mixed with medium-chain triglycerides and high-oleic canola oil
Rudkowska I, Roynette CE, Nakhasi MDK, Jones PJH. Metab Clin Exp 2006;55:391

Palm and partially hydrogenated soybean oils adversely alter lipoprotein profiles
Vega-Lopez, S, Ausman LM, Jalbert SM et al Am J Clin Nutr 2006; 84:54


Cholesterol lowering effects of nuts compared with a canola oil enriched cereal of similar fat composition.
Chisholm A, McAuley K, Mann J, Williams S, Skeaff M. Nutr Metab Cardiovasc Dis 2005; 15:284

Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes
West SG, Hecker KD, Mustad VA, Nicholson S, Schoemer SL, Wagner P, Hinderliter AL, Ulbrecht J, Ruey P, Kris-Etherton PMK.  Diabetologia 2005; 48:113


Dietary Mono- and polyunsaturated fatty acids similarly increase plasma apoliprotein A-IV concentrations in healthy men and women
Kratz M, Wahrburg U, Eckardstein A, Ezeh B, Assmann G, Kronenberg F.  J Nutr 2003; 133:1821

Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects
Smith R, Kelly C, Fielding B, Hauton D, Sliva K, Nydahl M, Miller G, Williams C. Br J Nutr 2003; 90:597


Effect of a rapeseed oil substituting diet on serum lipids & lipoproteins in children and adolescents with familial hypercholesterolemia
Gulesserian T, Widhalm K. J Am Coll Nutr 2002; 21:103

The effect of vegetable oil-based cheese on serum total and lipoprotein lipids.
Karvonen H M, Tapola N S, Uusitupa M I, Sarkkinen E S. Eur J Clin Nutr 2002; 56:1094

Dietary mono- and polyunsaturated fatty acids similarly affect LDL size in healthy men and women.
Kratz M, Gülbahçe E, Von Eckardstein A, Cullen P, Cignarella A, Assmann G. J Nutr 2002;132:715

Effects of dietary fatty acids on the composition and oxidizability of low-density lipoprotein.
Kratz M, Cullen P, Kannenberg F, Kassner A, Fobker M, Abuja PM. Eur J Clin Nutr 2002; 56:72

Different effects of diets rich in olive oil, rapeseed oil and sunflower-seed oil on postprandial lipid and lipoprotein concentrations & on lipoprotein oxidation susceptibility
Nielsen N, Perdersen A, Sandstorm B, Marckmann P, Hoy C. B J Nutr 2002; 87:489


Effects of diets containing olive oil, sunflower oil, or rapeseed oil on the hemostatic system.
Junker R, Kratz M, Neufeld M, Erren M, Nofer JR, Schulte H. Thromb Haemost 2001; 85:280

A diet containing rapeseed oil-based fats does not increase lipid peroxidation in humans when compared to a diet rich in saturated fatty acids.
Sodergren E, Gustafsson IB, Basu S, Nourooz-Zadeh J, Nalsen C, Turpeinen A, Berglund L, Vessby B. Eur J Clin Nutr 2001; 55:922


An olive oil-rich diet results in higher concentrations of LDL cholesterol and a higher number of LDL subfraction particles than rapeseed oil & sunflower oil diets
Pedersen A, Baumstark M, Marckmann P, Gylling H, Sandstrom B. J Lipid Res 2000; 41:1901


Dietary fats and lecithin-cholesterol acyltransferase activity in healthy humans.
Baudet MF, Jacotot B. Ann Nutr Metab 1998; 32:352

Effects of butter oil blends with increased concentrations of stearic, oleic and linolenic acid on blood lipids in young adults
Becker CC, Lund P, Holmer G, Jensen H, Sandstrom B. Eur J Clin Nutr 1999; 53:535

Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction
de Lorgeril M, Salen P, Martin J-L, Monjaud I, Delaye J, Mamelle N. Circulation 1999; 99:779

Effect of dietary alpha-linolenic acid on thrombotic risk factors in vegetarian men
Li D, Sinclair A, Wilson A, Nakkote S, Kelly F, Abedin L, Mann N, Turner A. Am J Clin Nutr 1999; 69:872


Oil blends containing hydrogenated or interesterified fats: differential effects on plasma lipids
Noakes M, Clifton P. Am J Clin Nutr 1998; 68:242

Fat-modified diets influence serum concentrations of cholesterol precursors and plant sterols in hypercholesterolemic subjects.
Sarkkinen ES, Uusitupa MI, Gylling H, Miettinen TA. Metabolism 1998; 47:744

Varying dietary fat type of reduced-fat diets has little effect on the susceptibility of LDL to oxidative modification in moderately hypercholesterolemic subjects.
Schwab US, Vogel S, Lammi-Keefe CJ, Ordovas JM, Schaefer EJ, Li ZG, Ausman LM, Gualtieri L, Goldin BR, Furr HC, Lichtenstein AH. J Nutr 1998; 128:1703


Effect of psyllium in hypercholesterolemia at two monounsaturated fatty acid intakes
Jenkins D, Wolever T, Vidgen E, Kendall C, Ransom T, Mehling C, Mueller S, Cunnane S, O'Connell N, Stechell K, Lau H, Teitel J, Garvey M, Fulgoni V, Connelly P, Patten R, Corey P. Am J Clin Nutr 1997; 65: 1524


Effect on serum lipids of monounsaturated oil and margarine in the diet of an Antarctic expedition
Matheson B, Walker K, Taylor D, Pterkin R, Lugg D, O'Dea K. Am J Clin Nutr 1996; 63:933

Canola and soybean oil supplementation of a mixed fat diet lowers serum cholesterol
Walker PM, Shane JM, Emken E, J Appl Nutr 1996; 48:125


Comparison of effects of n-3 to n-6 fatty acids on serum level of lipoprotein(a) in patients with coronary artery disease
Herrmann W, Biermann  J, Kostner GM, Am J Cardiol 1995; 76:459

Polyunsaturated fatty-acids result in greater cholesterol-lowering and less triacylglycerol elevation than do monounsaturated fatty-acids in a dose-response comparison in a multiracial study-group.
Howard B V, Hannah J S, Heiser C C, Jablonski K A, Paidi MC, Alarif L, Robbins DC, Howard WJ. Am J Clin Nutr 1995; 62:392

The effect of supplemental dietary fat on plasma cholesterol levels in lovastatin-treated hypercholesterolemic patients.
McKenney  JM, Proctor JD, Wright JT Jr, Kolinski RJ, Elswick RK Jr, Coaker JS, Pharmacotherapy 1995; 15: 565

Similar effects of rapeseed oil (canola oil) and olive oil in a lipid-lowering diet for patients with hyperlipoprotienemia
Nydahl M, Gustafsson I, Ohrvall M, Vessby B. J Amer Coll Nutr 1995; 14:643

Both dietary 18:2 and 16:0 may be required to improve the serum LDL/HDL cholesterol ratio in normocholesterolemic men
Sundram  K, Hayes K, Siru O. Nutritional Biochemistry 1995; 179

Plasma and lipoprotein lipid peroxidation in humans on sunflower & rapeseed oil diets
Turpeinen A, Alfthan G, Valsta L, Hietanen E, Salonen J, Schunk H, Nyyssönen K, Mutanen M. Lipids 1995; 30:485

The effects on serum lipoprotein levels of two monounsaturated fat rich diets differing in their linolenic and alpha-linolenic acid contents
Valsta L, Jauhiainen M, Aro A, Salminen I, Mutanen M. Nutr Metab Cardiovasc  Dis 1995; 5:129


Comparison of the effects of two diets rich in monounsaturated fatty acids differing in their linolenic/alpha-linolenic acid ratio on platelet aggregation
Freese R, Mutanen M, Valstra, LM, Salminen I. Thromb Haemost 1994; 71:73

A diet rich in monounsaturated rapeseed oil reduces the lipoprotein cholesterol concentration and increases the relative content of n-3 fatty acids in serum in hyperlipidemic subjects.
Gustafsson IB, Vessby B, Ohrvall M, Nydahl M. Am J Clin Nutr 1994; 59(3): 667-74

Effect of dietary fat selection on plasma cholesterol synthesis in older, moderately hypercholesterolemic humans
Jones P, Lichtenstein A, Schaefer E, Namchuk G. Arterioscler Thromb 1994; 14:542

Serum concentration and metabolism of cholesterol during rapeseed oil and squalene feeding
Miettinen TA, Vanhanen H. Amer J Clin Nutr 1994; 59:356

Similar effects of rapeseed oil (canola oil) and olive oil in a lipid-lowering diet for patients with hyperlipoproteinemia.
Miettinen TA, Vanhanen H. Am J Clin Nutr 1994; 59:356

Similar serum lipoprotein cholesterol concentrations in healthy subjects on diets enriched with rapeseed and with sunflower oil
Nydahl M, Gustafsson I, Ohrvall M, Vessby B. Eur J Clin Nutr 1994; 48:128


Effect of dietary alpha-linolenic acid and its ratio to linoleic acid on platelet and plasma fatty acids and thrombogenesis
Chan JK, McDonald BE, Gerrard JM. Lipids 1993; 28:811

Fatty Acid Composition and the Oxidation of Low-Density Lipoproteins
Corboy J. Biochem Med Metab Biol 1993; 49:25-35

Effects of canola, corn, and olive oils on fasting and postprandial plasma lipoproteins in humans as part of a national cholesterol education program Step 2 diet
Lichtenstein A, Ausman L, Carrasco W, Jenner J, Gualtieri L, Goldin B, Ordovas J, Schaefer E. Arterioscler Thromb 1993;  13:1533

Replacement of margarine on bread by rapeseed and olive oils: Effects on plasma fatty acid composition and serum cholesterol
Seppänen-Laakso T, Vanhanen H, Laakso I, Kohtamäki H, Viikari J. Ann Nutr Metab 1993; 37:161

Dietary monounsaturated fatty acids enhance cholesterol efflux from human fibroblasts. Relation to fluidity, phospholipid fatty acid composition, overall composition, and size of HDL3.
Sola R, Motta C, Maille M, Bargallo M T, Boisnier C, Richard JL, Jacotot B. Arterioscler Thromb 13(7):958-63


Rapeseed oil and sunflower oil diets enhance platelet in vitro aggregation and thromboxane production in healthy men when compared with milk fat or habitual diets
Mutanen M, Freese R, Valsta L, Ahola I, Ahlström A. Thromb Haemost 1992; 67:352

Replacement of butter on bread by rapeseed oil and rapeseed oil-containing margarine: Effects on plasma fatty acid composition and serum cholesterol
Seppänen-Laakso T, Vanhanen H, Kohtamäki H, Viikari J. Br J Nutr 1992; 68:639

Replacement of margarine on bread by rapeseed and olive oils: Effects on plasma fatty acid composition and serum cholesterol.
Seppänen-Laakso T, Vanhanen H, Laakso I, Kohtamaki H, Viikari J. Ann Nutr Metab 1992; 3:161

Double blind comparison of plasma lipids in healthy subjects eating potato crisps fried in palm olein or canola oil.
Truswell AS, Choudhury N, Roberts DCK. Nutr Res 1992; 12(Supplement 1):S43-52.

Effects of a monounsaturated rapeseed oil and a polyunsaturated sunflower oil diet on lipoprotein levels in humans
Valsta L, Jauhiainen M, Aro A, Katan M, Mutanen M, Arterioscler Thromb 1992; 12:50


Effects of canola oil on serum lipids in humans.
Bierenbaum ML, Reichstein RP, Watkins TR, Maginnis WP, Geller M. J Am Coll Nutr 1991; 10:228

Dietary alpha-linolenic acid is as effective as oleic acid and linolenic acid in lowering blood cholesterol in normolipidemic men
Chan JK, Bruce VM, McDonald BE. Am J Clin Nutr 1991; 53:1230

Effects of diets high in saturated fatty-acids, canola oil, or safflower oil on platelet-function, thromboxane-B2 formation, and fatty-acid composition of platelet phospholipids.
Kwon JS, Snook JT, Wardlaw GM, Hwang DH. Am J Clin Nutr 1991; 54:351

Serum lipid and apolipoprotein concentrations in healthy men on diets enriched in either canola oil or safflower oil
Wardlaw G, Snook J, Lin M-C, Puangco M, Kwon J. Am J Clin Nutr 1991;54:104


Accumulation of eicosapentaenoic acid in plasma phospholipids of subjects fed canola oil.
Bruce VM, McDonald BE. Lipids 1990; 25:598


Comparison of the effects of canola oil and sunflower oil on plasma lipids and lipoproteins and on in vivo thromboxane A2 and prostacyclin production in healthy young men
McDonald B,  Gerrard J, Bruce V, Corner E. Am J Clin Nutr 1989; 50:1382


Dietary fats and lecithin-cholesterol acyltransferase activity in healthy humans
Baudet MF, Jacotot B. Ann Nutr Metab 1988; 32:352


Influence of long-term diet modification on platelet function and composition in Moselle farmers
Renaud S, Godsey F, Dumont E, Thevenon C, Ortchanian F, Martin JL. Am J Clin Nutr 1986; 43:136